Chemical biologists are making significant progress in discovering and characterizing high-quality chemical probes. In this issue, we feature Commentary and Review Articles that capture opinions and ...

New molecule halts mitochondrial DNA loss before it triggers inflammation. When environmental stress harms DNA, it can set off a cascade of failures linked to heart conditions, neurodegeneration and ...

Chemical probes are small‐molecule tools that elucidate the functions of biological targets, thereby providing invaluable insights into cellular processes and disease mechanisms. Their use in drug ...

Researchers outline how they used a chemical probe to light up interlocking peptides. Their technique will help scientists differentiate synthetic peptides from toxic types found in Alzheimer's ...

Tuberculosis (TB) is an infectious disease that kills more than a million people worldwide every year. The pathogen that causes the disease, Mycobacterium tuberculosis, is deadly in part because of ...