Schizophrenia (SCZ) is a psychiatric disorder with onset in adulthood, and is thought to be triggered by some combination of environmental factors and genetics. However, the exact cause of the ...

In 1992, Judith Frydman, PhD, discovered a molecular complex with an essential purpose in all of our cells: folding proteins correctly. The complex, a type of "protein chaperone" known as TRiC, helps ...

Tel Aviv University researchers have made a discovery that could enhance our understanding of genetic mutations and their role in brain development. The study, "Protective inherited mutations in ...

Researchers at Baylor College of Medicine have uncovered a previously unrecognized mechanism by which inherited calcium channel mutations disrupt early brain development and predispose children to ...

Schizophrenia is thought to affect 1 in 300 people, or about 0.32 percent of the global population, and treatment options are limited because of a poor understanding of the mechanisms underlying the ...

Millions of adults have atrial fibrillation - an irregular beating of the upper chambers of the heart that yields increased risk of heart failure, stroke and death. Many genetic mutations in the ...

Psoriasis is a chronic inflammatory immune-mediated disease that causes patches of skin to become flaky or sore. The current cause of the condition is unknown and it is estimated that 125 million ...

Low-density lipoprotein receptor-related protein 4 (LRP4) has emerged as a central modulator of skeletal patterning and homeostasis through its capacity to regulate canonical Wnt/β-catenin signalling.

Figure 3. Docking of ADNP_Glu931Glyfs12 to the PTB protein. (A) The results of docking ADNP_Glu931Glyfs12 (light orange) to the PTB protein (PDB code 3DXC, navy blue) in the 934-941 amino acid region ...

Researchers at Baylor College of Medicine have uncovered a previously unrecognized mechanism by which inherited calcium channel mutations disrupt early brain development and predispose children to ...