What Is Modeyso Used For? Modeyso is used to treat a type of recurrent brain cancer known as a diffuse midline glioma with a specific genetic mutation known as histone 3 (H3) K27M. Diffuse midline ...
Diffuse midline glioma (DMG) is a rare form of brain tumor that mostly occurs in children and young adults. It can be highly aggressive and difficult to treat. DMGs form within the central nervous ...
Modeyso is the first FDA-approved systemic therapy for H3 K27M-mutant diffuse midline glioma, targeting both adult and pediatric patients. Clinical trials demonstrated a 22% overall response rate with ...
Like other tumors that arise in midline structures of the brain, most DIPGs are histone H3-mutated tumors that harbor H3K27M mutations. DIPG typically originates in the ventral pons, which is the ...
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