In 2006, Rothemund published the first paper on DNA origami, a technique that provides simple yet exquisite control over the design of molecular structures at the nanoscale using nothing more than DNA ...
In one sentence: DNA origami is a self-assembly technique that folds a long single-stranded DNA molecule into precisely defined nanoscale shapes using hundreds of short, computer-designed staple ...
Similarly to the artistic technique of folding paper into ornate shapes, DNA origami is a self-assembling technique of precisely folding single-stranded DNA scaffolds into well-defined nanostructures.