Researchers show two distinct MECP2 mutations in Rett syndrome elevate miRNA-126-3p, lowering ZO-1 and weakening blood-brain ...

Many cells comprise the tumor microenvironment, but endothelial cells are particularly crucial. They line blood vessels, regulating blood flow and inflammation, and their cell junctions are the ...

The formation of blood vessels is a complex process involving the interplay of proteins and mechanic forces. In two studies, a research team has uncovered new mechanisms in blood vessel formation. The ...

The blood-brain barrier protects the central nervous system by tightly regulating what crosses between the two compartments. Neurons are vulnerable if the barrier suffers damage or weakens with age, ...

Cell-to-cell junctions were visualized by ZO1-GFP, and the dynamics of cell junctions were captured by movies. When the cells indicated by * were spontaneously stretched, a continuous belt of cell ...

The glycocalyx emerges as an active endothelial system whose structure, metabolism, and shear-dependent regulation integrate mechanical forces with vascular signaling. Disruption of this system ...

Treating brain diseases like tumors and Alzheimer's is notoriously difficult due to the blood-brain barrier (BBB), which blocks most drugs. While nanomedicine offers a promising solution, its path to ...

National Institute of Neurological Disorders and Stroke investigators at the National Institutes of Health traced meningeal ...