Schematic diagram depicting the mechanism of the rigid matrix regulating cell glycolysis in degenerated NPCs. In degenerated NP tissue, MRTF-A was activated by increased matrix stiffness and ...

Human bodies are usually described as chemical engines, powered by glucose and oxygen. Yet a wave of new research suggests ...

The researchers say it was taught in biochemistry class for many decades that glycolysis occurred uniformly in the cytosol, or the fluid matrix of the cell. But when the Johns Hopkins team examined ...

The mechanical properties of tissue matrix are crucial for maintaining cell health and function. With aging, tissue matrix loses its mechanical integrity and exhibits altered biophysical properties, ...

Intervertebral disc degeneration (IVDD) is a leading cause of chronic back pain and disability, impacting millions of people worldwide. Characterized by the breakdown of the disc’s extracellular ...