The analytical workflow begins with the separation of the complex protein mixture, often utilizing liquid chromatography (LC) or capillary electrophoresis (CE) coupled directly to the MS system.

To-date, proteomic analysis has been severely limited in scale and resolution. Analyzing protein samples using an intact, single-molecule approach holds the promise to achieve improved dynamic range, ...

Paleontology has just reached a major milestone with the discovery of intact proteins in fossils dating back to the Miocene. This breakthrough, published in Nature, is based on the analysis of ...

Uniform protein labeling in intact tissues is a challenge. An approach that allows antibodies to seep within organs could label proteins in millions of cells. Conventional protein-tagging methods, ...

The field of proteomics is undergoing a revolution to better quantify proteins and unlock the dynamic and valuable source of functional biological insight held in the proteome. Single-molecule protein ...