Researchers at the University of Toronto have discovered that bacteria can drive stem cell regeneration to repair the intestinal lining after injury—uncovering an unexpected way in which the gut ...

Cells on the inner surface of the intestine are replaced every few days. But, how does this work? It was always assumed that cells leave the intestinal surface because excess cells are pushed out. In ...

Human organoids are 3D cell cultures derived from adult stem cells and maintain the variable distribution of epithelial cells seen in primary tissue. They can recapitulate the mechanisms of epithelial ...

Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem cells become absorptive or secretory cells. Manipulating the enzyme OGDH ...

Gut support cells communicate with surprising precision – like brain neurons – using tiny extensions to send instructions to the stem cells responsible for maintaining and healing the intestine. The ...

Researchers have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. A professor of pediatrics-developmental biology and an assistant professor of ...

A new study reported in Nature has determined that the amino acid cysteine could promote regeneration among cells in the small intestine. The work showed that cysteine can activate an immune signaling ...

The interplay between the circadian clock, intestinal stem cell niche, and epithelial cell fate is shaping our understanding of how gut homeostasis and cellular regeneration are regulated. Recent ...

A recent study comparing young and aged mouse intestinal tissues revealed a delicate balance between IFN-γ signaling and ERK/MAPK signaling as crucial for maintaining the intestinal stem cell ...

A new study led by Hartmut Geiger at the University of Ulm, Germany, and Yi Zheng and Kodandaramireddy Nalapareddy, Cincinnati Children's Hospital Medical Center (CCHMC), USA reveals that age-related ...