Drosophila melanogaster has long served as a powerful model for dissecting the principles of tissue homeostasis and regeneration. Within the adult midgut, intestinal stem cells (ISCs) perform the ...

Image Caption: The signaling pathways involved in the intestinal stem cell niche and cell fate determination. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and ...

The interplay between the circadian clock, intestinal stem cell niche, and epithelial cell fate is shaping our understanding of how gut homeostasis and cellular regeneration are regulated. Recent ...

A recent study comparing young and aged mouse intestinal tissues revealed a delicate balance between IFN-γ signaling and ERK/MAPK signaling as crucial for maintaining the intestinal stem cell ...

In a key advance for regenerative medicine and gut health, scientists from Duke-NUS Medical School and Nanyang Technological University, Singapore (NTU Singapore) have uncovered a precise and ...

Stem cells in most organisms typically take cues from adjacent cells. But new research from the Stowers Institute for Medical Research has found that stem cells in the freshwater planarian Schmidtea ...