This article examines the use of femtosecond (fs) laser ablation for site-specific TEM sample preparation in a FIB-SEM. Various workflows are shown facilitating TEM lamella preparation of regions of ...

Sample preparation plays a crucial role in bioanalytical analysis involving chromatography. Insufficient sample preparation, such as skipping protein precipitation, phospholipid removal (PLR), ...

Cryo-electron tomography (cryo-ET) can provide invaluable insights into subcellular structures in their native environment at ...

The proper preparation of heat sensitive samples is a critical aspect of laboratory work across various industries. Ensuring that samples maintain their integrity throughout the sample preparation ...

Although next-generation sequencing (NGS) keeps giving—exploring the human genome and revolutionizing our knowledge of health and disease—it needs to take a little, too. At the very least, NGS ...

Whole blood sample stability as an analytical parameter should be assessed when developing pharmacodynamic flow cytometry assays. Sample stability will determine the robustness of detecting not only ...

In recent decades, the preparation of samples for transmission electron microscopes has transformed, thanks to the introduction of focused ion beam (FIB) instruments. Known as either single-beam or ...

Every time there is an update to a standard, especially an overarching one like the ISO 10993-12 standard that covers sample preparation recommendations, it comes with a slight dose of anxiety. This ...

Proper quality measures are vital in all areas of clinical laboratory testing to prevent or avoid carryover between samples, as well as to minimize the risk of false-positive results. The sample ...

Proteins are workhorses that carry out most of the biological functions in our cells. While the genes we inherit from our parents, our so-called genome, are fixed and usually remain unchanged ...