Most of the activities that go on inside cells—the activities that keep us living, breathing, thinking animals—are handled by proteins. They allow cells to communicate with each other, run a cell’s ...
Artificial intelligence (AI) is reshaping the scientific landscape, offering fantastic solutions to some of the most pressing global challenges. From combating climate change to transforming ...
The proteins found in nature represent only a tiny fraction of the nearly limitless protein structures that could theoretically exist. By designing proteins de novo—from scratch—scientists can more ...
In biology, the binding of cellular proteins to molecules called ligands produces myriad functions essential for life, ...
Funding: W.C.R. acknowledges support from the NIH (grant no. 5R35GM138030) and NSF (CAREER Grant no. 1845363), A.J.B. acknowledges support from the Human Frontiers Science Program grant (RGY0080/2020) ...
Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...
The ability to alter protein binding can create tailored therapeutics with reduced side effects, sensitive diagnostic tools, targeted drug delivery and sustainable bioremediation. BIRMINGHAM, Ala. – ...
The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...
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