The Golgi apparatus transports and modifies proteins in eukaryotic cells. How have scientists studied dynamic protein movements through the Golgi? One of the principal observations by Rothman's group ...
Scientists have long sought a robust picture of how the Golgi complex, an organelle critical to the post-translational modification and sorting of newly synthesized proteins, operates. The Golgi ...
Our cells carry out hundreds of thousands of important functions every day, all of which are carefully orchestrated at a microscopic scale. However, the precise mechanisms that influence the luminal ...
Golgi membrane-associated degradation (GOMED) selectively degrades proteins by using K33-linked polyubiquitin as an 'eat-me' signal, which is recognized by the adaptor protein optineurin (OPTN). Mice ...
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