Clonal haematopoiesis of indeterminate potential (CHIP) is an ageing-related condition associated with a substantial fraction of leukocytes descending from a single somatically mutated haematopoietic ...

Single-cell biology has transformed how we decode cellular heterogeneity, but a new frontier is emerging: understanding what individual cells do, not just what they express. The ability to observe ...

Scientists at the Icahn School of Medicine at Mount Sinai, in partnership with the Multiple Myeloma Research Foundation (MMRF ...

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to reveal disruptions in gene function in three brain regions of patients with ...

Single-cell transcriptomics identifies three discrete mouse trabecular meshwork subtypes and demonstrates that an Lmx1b glaucoma mutation drives mitochondrial dysfunction and elevated intraocular ...

Single-cell analysis is a ubiquitous laboratory technique that allows researchers to probe the myriad biomolecular states of cells. Single-cell assays can reveal gene and protein expression patterns, ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

Capturing spatial information is essential to elucidate how cells function and interact within their native tissue environment. However, the initial spatial transcriptomics techniques have several ...

Understanding the genetic mechanisms linking genome variations, such as single-nucleotide polymorphisms (SNPs), to phenotypes ...

10x Genomics is stepping up to buy Scale Biosciences and its single-cell profiling solutions, with plans to implement them within the company’s Chromium platform. The deal for the recent Fierce ...

Single-cell RNA-seq (scRNA-seq) has spent the past decade maturing into a foundational technology. Over that time, the technology has both laid the foundation for building cell atlases and allowed ...