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Mastering bias-free epidemiology study designs

Observational study designs like cohort, case-control, and cross-sectional are the backbone of epidemiology, but each comes with unique strengths, limitations, and bias risks. Understanding these ...
Nature

Active-comparator design and new-user design in observational studies

Over the past decade, an increasing number of observational studies have examined the effectiveness or safety of treatments for rheumatoid arthritis. Unlike randomized controlled trials (RCTs), ...
Nature

Psychiatric neuroimaging designs for individualised, cohort, and population studies

The “traditional” model in psychiatric neuroimaging, characterised by small, cross-sectional, and observational studies has historically dominated research endeavours. Over the last decade, numerous ...
News Medical

Insight into the Different Clinical Trial Study Designs

Clinical trials are well-controlled and designed experiments that aim to prove that an Investigational Medicinal Product (IMP) is effective. Clinical trial data is submitted to the national health ...
ascopubs.org

Performance of Two-Phase Designs for the Time-to-Event Outcome and a Case Study Assessing the Relapse Risk Associated With B-ALL Subtypes

As biomarker studies employ increasingly complex and expensive genomics and other correlative methods, it is increasingly important to rigorously design these studies and analyze the downstream ...
Forbes

Jay Bhattacharya Called Test-Negative Study Design ‘Crap.’ Here’s How We Know Whether Vaccines Measured With It Are Effective

WASHINGTON, DC - MARCH 5: Jayanta Bhattacharya, U.S. President Donald Trump's nominee to be Director of the National Institutes of Health, speaks at his confirmation hearing before the Senate ...