A twin-screw extruder can be used as a continuous wet granulator. The ongoing development and commercialization of continuous manufacturing for oral solid-dosage (OSD) pharmaceuticals is creating a ...

The authors review developments in wet granulation using a twin-screw extruder. As a result of changing philosophies towards continuous manufacturing, new equipment is being introduced into ...

In dry granulation, powders bind because of the application of mechanical stress. As particles are forced to be within closer proximity, entrained air is forced out, bulk density increases, and a ...

Granulation is a critical unit operation in pharmaceutical manufacturing, where fine powders are agglomerated into granules to improve flow properties, uniformity, and compaction performance. The ...

Granulation is important in the pharmaceutical industry because of increased pressures due to the costs of manufacturing solid dosage forms. Granulation forms coarser collections from fine powder.