For decades, the central dogma of molecular biology—DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease. This model explained ...

A new method developed at Baylor College of Medicine and collaborating institutions allows researchers to better understand how RNA works. The method is a powerful strategy for identifying intricate ...

Researchers led by Davide Incarnato at the University of Groningen have demonstrated that the FDA-approved cancer drug mitoxantrone works against RNA not simply by attaching to it, but by forcing it ...

RNA plays a vital role in how our genes are expressed and how diseases develop. Yet, because RNA molecules constantly change shape, understanding how they work has long been a major scientific ...

The AIRFoundry facility — funded by a six-year, $18 million National Science Foundation grant — brings together researchers ...

RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA vaccines and double-stranded RNA (dsRNA) therapies. But while health care ...

Multiple forms of double-stranded RNA (blue, magenta, orange structures) cross cell membranes with the help of a conserved protein located in novel sites (colored by depth) throughout the roundworm's ...

Look inside a brain cell with Huntington’s disease or ALS and you are likely to find RNA clumped together. These solid-like clusters, thought to be irreversible, can act as sponges that soak up ...

New research shows how certain orphan noncoding RNA — oncRNA — can be predictable enough to be a ‘bar code’ identifying ...

The molecular pathways involved in antiviral defenses and counter-defenses in host-pathogen systems remain unclear. Researchers have used Neurospora crassa as a model organism to explore how RNA ...

Researchers developed STRIPE, a targeted long-read RNA sequencing tool that identifies disease-causing variants missed by ...